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2 edition of Studies on the adherence of neisseria gonorrhoeae to mammalian cells and tissues. found in the catalog.

Studies on the adherence of neisseria gonorrhoeae to mammalian cells and tissues.

Graham Michael Tebbutt

Studies on the adherence of neisseria gonorrhoeae to mammalian cells and tissues.

by Graham Michael Tebbutt

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Published by University of Birmingham in Birmingham .
Written in English

Edition Notes

Thesis (Ph.D) - University of Birmingham, Dept of Microbiology.

ID Numbers
Open LibraryOL20008688M

Aug 21,  · Neisseria gonorrhoeae has developed antimicrobial resistance (AMR) to all drugs previously and currently recommended for empirical monotherapy of vitro resistance, including high-level, to the last option ceftriaxone and sporadic failures to treat pharyngeal gonorrhoea with ceftriaxone have emerged. In response, empirical dual antimicrobial therapy (ceftriaxone Cited by: • Test Neisseria gonorrhoeae by Real-Time PCR(Reflex to antibiotic resistance by Molecular Analysis) developed by MDL, offers a valuable diagnostic tool for the reliable detection b Clinical experience and published studies suggest that azithromycin is safe and effective. • Due to the concerns for developing patterns of antimicrobial.

studies or on a small subset of the N. gonorrhoeae population (Gradetal.,)). Hence, there is a need for studies aimed at understanding the global N. gonorrhoeae population structure at the whole genome scale. Past AMR studies using limited numbers of gonococcal strains from specific geographic. Molecular diagnostics and characterization of Neisseria gonorrhoeae Stig Ove Hjelmevoll A dissertation for the degree of Philosophiae Doctor January Molecular diagnostics and characterization of Neisseria gonorrhoeae. 2 Content Neisseria gonorrhoeae isolates in Norway in

Apr 28,  · Antibiotic resistance in Neisseria gonorrhoeae: Origin, evolution, and lessons learned for the future. Annals of the New York Academy of Sciences, (1), EE This entry was posted in adaptation, evolutionary medicine, selection in action and . Oct 28,  · The value of monitoring antimicrobial resistance is particularly significant for Neisseria meningitidis and Neisseria gonorrhoeae diseases, even if it is for different reasons. Although there is.

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Studies on the adherence of neisseria gonorrhoeae to mammalian cells and tissues by Graham Michael Tebbutt Download PDF EPUB FB2

Start studying Bacterial Adherence + Neisseria gonorrhoeae. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Search. Upregulation of production of antimicrobial peptides by epithelial cells 3.

Phagocytosis of adherent organisms - N. gonorrhoeae usually adheres to genitourinary tissues - Pili + other. Adhesion of Neisseria gonorrhoeae and disease.

Tramont EC. Adhesion of gonococci to mucosal epithelial cells appear to be a critical step in the pathogenesis of gonococcal infection. Parameters affecting adhesion, the antigens involved in adhesion and the human antibody response that blocks adhesion have been by: 6.

Adherence of Neisseria gonorrhoeae and other Neisseria to any understanding of the role of adhesion in the pathogenesis of neisserial infections are clinico-pathological studies of the natural disease.

Watt P.J., Ward M.E. () Adherence of Neisseria gonorrhoeae and other Neisseria Species to Mammalian Cells. In: Beachey E.H. (eds Cited by: The major outer membrane porin (PorB) expressed by Neisseria gonorrhoeae plays multiple roles during infection, in addition to its function as an outer membrane pore.

We have generated a panel of mutants of N. gonorrhoeae strain FA expressing a variety of mutant porB genes that all function as porins.

We identified multiple regions of porin that are involved in its binding to the Cited by: Bacterial Adherence - Neisseria gonorrhoeae. Virulence Mechanisms of Pathogenic Bacteria. Adheres to genitourinary tract tissues in particular urethral/cervical epithelial cells - using pili and other surface proteins to attach to host cells at pili tip = PilC protein which functions as an adhesin and mediates adherence to host cells.

Neisseria gonorrhoeae. Neisseria gonorrhoeae rarely causes conjunctivitis but is important to consider because infection can lead to corneal ulceration and blindness. 8,9 The organism binds avidly to surface receptors on the conjunctivae and cornea, triggering the release of bacterial toxins and inflammatory enzymes that damage the corneal.

Bacterial Adhesion to Cells and Tissues; especially those of Escherichia coli and Neisseria gonorrhoeae. TIF mediates the colonization of mammalian host tissue, such as intestinal mucosa.

Neisseria gonorrhoeae, also known as gonococcus (singular), or gonococci (plural) is a species of Gram-negative diplococci bacteria isolated by Albert Neisser in It causes the sexually transmitted genitourinary infection gonorrhea as well as other forms of gonococcal disease including disseminated gonococcemia, septic arthritis, and gonococcal ophthalmia Betaproteobacteria.

Molecular Analysis of Virulence Determinants of Neisseria gonorrhoeae. Authors; to eukaryotic cells and tissues. In: Danielson D, Normark S (eds) Genetics and immunobiology of pathogenic neisseria. University of Umea, Sweden, pp – Google Scholar.

Watt PJ, Ward ME () Adherence of Neisseria gonorrhoeae and other Author: Thomas F. Meyer, R. Haas, R. Halter, P.

Nickel, J. Pohlner, A. Stern, J. Clarke, H. Delius, M. Neisseria gonorrhoeae. are a cause of pelvic inflammatory disease in women, which can lead to serious reproductive complications including tubal infertility, ectopic pregnancy, and chronic pelvic pain.

Prevention of sequelae and of transmission to sexual partners relies largely on prompt detection and effective antimicrobial. Most of the information on bacterial invasion comes from studies with tissue culture cells and human fallopian tube organ culture.

After the bacteria attach to the nonciliated epithelial cells of the fallopian tube, they are surrounded by the microvilli, which draw them to the surface of the mucosal cell. We use cookies to make interactions with our website easy and meaningful, to better understand the use of our services, and to tailor advertising.

Neisseria meningitidis and Neisseria gonorrhoeae are obligate human pathogens and the other we examine the process of adhesion of Neisseria species to target mammalian host cells and tissues, by focusing on PilT also mediates loss of piliation and progression from a localised to a diffuse pattern of adherence to epithelial cells Cited by: Oct 01,  · The molecular mechanisms used by the gonococcus to initiate infection exhibit gender specificity.

The clinical presentations of disease are also strikingly different upon comparison of gonococcal urethritis to gonococcal cervicitis. An intimate association occurs between the gonococcus and the urethral epithelium and is mediated by the asialoglycoprotein receptor.

Gonococcal interaction Cited by: Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country.

Adhesins are cell-surface components or appendages of bacteria that facilitate adhesion or adherence to other cells or to surfaces, usually the host they are infecting or living in.

Adhesins are a type of virulence factor. Adherence is an essential step in bacterial pathogenesis or infection, required for colonizing a new host. Adhesion and bacterial adhesins are also a potential target for.

Pathogenic Neisseriae: Gonorrhea, Neonatal Ophthalmia and Meningococcal Meningitis (page 5) the meningococcus, is identical in its staining and morphological characteristics to Neisseria gonorrhoeae.

However, which attach to epithelial cells of the nasopharyngeal and oropharyngeal mucosa, cross the mucosal barrier, and enter the. Jan 11,  · Clinical manifestations of Neisseria gonorrhoeae Gonococci most often colonize the mucous membrane of the genito -urinary tract or rectum. There, the organisms may cause a localized infection with the production of pus or may lead to tissue invasion, chronic inflammation, and fibrosis.

The human pathogens, Neisseria meningitidis and Neisseria gonorrhoeae are exquisitely adapted to life within the human mucosa, their only natural niche. meningitidis is the causative agent of rapidly transmissible meningitis and septic shock.

Vaccines developed to control this pathogen can be rendered ineffective by the pathogen's ability to undergo antigenic variation. Feb 19,  · Immunity to N.

gonorrhoeae is a topic that until recently has been hard to define, because there is currently no clearly established state of immunity to gonorrhea in humans, which are the only natural host for this infection. Furthermore, until recently, only one animal model of genital tract infection has been developed, known as the estradiol-treated female mouse model.

However, N. Acknowledgement The World Health Organization wishes to acknowledge the support of the United States Agency for Inter-national Development (USAID) in the production of this docume.Mar 01,  · Pili of N. gonorrhoeae are composed of highly variable major pilus subunits (PilE) that comprise the bulk of the pilus fibre and PilC that is a minor pilus-associated protein.

PilC is essential for pilus biogenesis (Jonsson et al., ), and acts as an adhesin at the tip of the pilus fibre (Rudel et al., ).Upon adherence of piliated Neisseria to the host cell, the type IV pili induce.Disclaimer: ITIS taxonomy is based on the latest scientific consensus available, and is provided as a general reference source for interested parties.

However, it is not a legal authority for statutory or regulatory purposes. While every effort has been made to provide the most reliable and up-to-date information available, ultimate legal requirements with respect to species are contained in Biological classification: Species.